So, the mising bolt is likely not the cause of any problem, yet. it is a major hold down for the cam block/bearing. Being gone makes me suspicious the threads are stripped and the PO left it out because it wouldn't tighten up.
I'm still curious, on the opposite end of the cam from where the missing bolt is, there should be a bolt running into the end of the cam, which has a large thick washer between the bolt head and the end of the cam. Got one?