Yeah, if that's the field you've narrowed it to, I'd go for the big KLR, although, if it were ME, I'd go for the older, pre-redesign model ('08, '09?). Way more of an "experience base" out there, which is a good thing.
I just picked up a little KL250 (aka Super Sherpa) just before Christmas. Great little bike, tons of fun, and getting 70 mpg!
Good luck with it, whichever way you go. Keep us informed!
Kirk