1974 CB750, K&N air filter with the stock airbox, 4 into 1 header with Kerker muffler. Stock motor, stock Kei Hin carbs.
With this setup I would guess that you will need to turn your pilot screws inwards about 1/8 to 1/4 less than the stock setting.
You will determine this by how the engine responds to pick up upon throttle twist under load.
Mark your throttle, set pilots to stock position (or leave them where you have them now), and test drive. Top gear at 15 MPH whack the throttle to the one half of total travel position. The engine should pick up smoothly, and predictably without stumble. If it wheezes and loses power, then turn all the screws inwards 1/8 turn and repeat the test drive. Keep turning the pilot screws inward and test drive until the engine does accelerate smoothly and predictably.
Here is why.
Your carbs don't have accelerator pumps. When the throttle is suddenly opened, the carb throat vacuum is mostly lost as it is quickly equalized by the inrush of air. It is the vacuum that pulls the fuel up from the fuel bowls (under these low speed conditions). Lose the vacuum, and although there is plenty of air going to the engine, it starves for fuel. Later carbs overcome this with the accelerator pump, which shoots a stream of gas in the carb bore when the throttle is twisted. Since accelerator pumps are absent on your model carbs, the idle mixture is set over-rich at idle so opening the slides still keeps the mixture in the combustion range, so long as not too much air is introduced. Hench the 1/2 throttle travel twist.
The K&N filter induces less pressure drop across it's membrane compared to the stock item, causing some reduced vacuum and a leaning effect on carb jet flow. Further, the Kerker's lesser back pressure (compared to stock) allows more oxygen to replace the spent gases in the combustion chamber, setting up a requirement for more fuel needed at idle.
It could be, that the filter and exhaust changes also require a main jet and slide needle adjustment. But, that would be determined by a Dyno test, or a test track and spark plug tip reading.
Ethanol blended fuel can also mess up ideal carb settings and make stock to-the-book settings wrong or just "off" a bit.
All this assumes the engine and carbs are working as well as when new.
Cheers,