Two dead cylinders would def. make some noise, especially via backlash in the gearbox. It would pretty much sound like the motor was about to come apart due to, as you said, having to drag those other two cylinders through their combustion cycle. The point not breaking contact would cause either 1 and 4 not to fire or 2 and 3 not to fire. Wonder if its just frozen, way out of adjustment or the spring is worn out on that point? Been awhile since Ive been in there.