I think we sometimes forget WHY OEMs do things. Mass production automobiles were meant to be relatively maintenance free without the need for many adjustments by the owner. Motorcycles... well these were always performance machines. If you have to adjust the valves on something then it's implied that there's going to be the need for some tuning and tinkering and mechanical ability. Single carbs worked on cars and provided good drivability with minimal headache for the owner. Some even made quite a bit of power. But take a closer look. In 1970 your average hydraulic lifter 7 liter engine made around 400hp with a single quad carb (or more like 365-390 actually). Or around 57hp per liter. In 1970 a CB750 was making around 90hp per liter. Think about that a second.
All else being equal you'll lose efficiency going to one carb in the name of less maintenance and adjustment. Given the nature of naturally aspirated engines you'd have to do A LOT of work to make up for that loss. Increasing displacement, increasing RPMs (read: maybe better internals and valvetrain), bigger cam, bigger valves, head porting, more thought into the exhaust than just buying a MAC... In other words, if you're looking for performance and have half a brain you WOULDN'T be doing that.
If you're looking for Grandma's 1968 Olds wagon that made 40hp per liter but was rock solid, never in the shop and started easy on a cold Wisconsin morning then by all means switch to a single carb on your CB750.
Or perhaps maybe a Camry beckons.