Difference can sometimes be difficult to feel except for black smoke (plugs) when rich, sneezing carb on low lift when lean pilot circuit.
You need to ride the bike on a specific throttle height, check sparkplug and read it.
Air screws/fuel screws affect a steady cruising up to around 100kmh (60mph).
https://www.crankshaftcoalition.com/wiki/Reading_spark_plugsCarbs can be jetted for perfect plug color, but might respond very bad on twisting the throttle.
Read sites where Air/Fuel ratio is described. Good cruising ratio around 14:1 while best torque around 12.5:1.
I have just finished my carbs. Needles and main jets could be 1 step too lean noticed when twisting from 100kmh (60 mph). It ran fine otherwise.
My CB750 K6 stock carbs never needed other needle jets (emulsifier tubes) with pods and 836 + cam etc. Only 1 step richer needle when not using the restrictive stock exhausts ( HM341). [Same carbs have today 1 step richer needles with stock engine on HM300 replica than HM341 (when sitting on my K6 when stock) on my stock K2.]
And much richer main jets. Air screws less opened as well.
I have done 3500km on my K6 this year (April-May) to verify the carbs, plugs AND the throttle response. Not stock carbs so all jets were not known and needed to be changed except for needle tapers and throttle cut outs.
If you run stock carbs, you will find a good working base setting if searching what others have done.
Main jet and needle height are dependent on how open your exhaust is. When this can breathe, pods can open it up even more. Restrictive exhaust, pods will not increase flow much more in need of more fuel.
Like open windows and doors home. 1 door open, not much more flow inside, then open a window in another room can cause a storm inside when IN and EX start to work together.
Very important start point on other carbs than stock, needle jets (emulsifier tubes), around 3-5mm throttle lift. Must be right!! Not fixed by lower the needles loosing power on higher lifts and compensate further by increasing pilot jet which give too rich idle.
I have noticed that this picture describes carb jetting very well.
fuel.