Just from the age of the photo, you kinda have to guess 40's. So, it couldn't be a Honda, since wasn't he making engine propellers for the Jap Zeros? lol
If it isn't a Harley, you kind of have to assume is an Indian. Most Brit bikes of that era had MUCH more narrow tanks. And were the rest of the Japanese makers hitting US shores by then? If so, probably much more spindly looking, like the Brit bikes.