I get 45-50 -ish in stock trim with Uni Nu 4055 air filters. The 78 is about 5 MPG higher than the earlier bikes, even with the stock paper filter.
Miles to reserve depends on tank size, and length of the stand pipe on the fuel valve. The 550's have three different styles of fuel valves and two different tank sizes.
I should add that the one and only Cb550 I had with a 16 T front sprocket got about 5-10 MPG worse than the rest. (Uni NU 4055 filter and Mac 4 into 1 exhaust system).
Cheers,