This topic (inline filters/loops in the fuel lines) has been bandied about on this forum before. From my personal experience I can tell you that I have in-line filters and an associated down/up loop in the fuel lines on my 550, and I've done it this way for 35 years with absolutely no problems. Others have posted the same. I agree that in an absolute sense this setup may deliver less fuel per second to the bowls, but in practicality this has never been an issue for me. Back in the 70's I road the 550 across rural Nevada and once spent almost 1/2 hour at 100 mph. Even that extreme situaton did not exceed the fuel demands of my system. The reason I like the inline filters is simply this- I think they do a lot better job of filtration than the petcock screens. No small rust particles clumping up in the bowls, etc.
There IS a science to this.
The down and up loop traps air at the high points in the fuel route. When there is plenty of gas in the tank, the head pressure is sufficient to move past these trapped bubbles. It is when the fuel level in the tank gets low and creates low head pressure, that it becomes problematic to fight the reverse pressure created by the air bubbles in the lines with such a low head pressure. The effect is that you have less usable fuel in the tank, or you run the engine with lower float levels, leaning the engine mixtures. The significance of the latter depends on how the engine is tuned. It does matter if it is in stock tune.
You cannot keep bubbles out of the line with these carbs, as each time the float valve opens, air at the top of the float chamber rises into the fuel inlet/lines. When the fuel line routing does allow the air to rise to the fuel value, it becomes trapped.
In line filters can do "a better job" of filtration. For a while, anyway. But, such a level is unnecessary. You don't need to trap particles smaller than will fit through fuel metering orifices. Such particles simply travel through the engine and out the exhaust. Anyway, it is better to keep rust from the tank, than cover it with a band aid. ALL the stock SOHC4 screens and filters stop particles that can block fuel orifices.
I have yet to find anyone state they replace the filter(s) at some regular intervals or provide a rationale for its replacement/maintenance schedule.
For the non-scientific, I suppose I should add that I haven't used an inline filter on my SOHC4s since 1975 and have never had a carb block from particulates sourced from the fuel tank. (Gum and varnish formations inside the carb won't be blocked by ANY filter.)
Further, I have been able to keep the engine running with the fuel in the tank running down to only 0.1 gallons left. (Finally found a filling s station.)
As a parallel, I do know people that have successfully jumped off roofs. I also know some (not all) that got hurt in the process. Such is life.
Cheers,