Couple of things, high vacuum means slide is low, ergo, low vacuum means slide is high allowing more air to pass under it.
Carb sync is the last thing you do after full service, check/re-set valve adjustment, check ignition timing, sync carbs.
If reading is real low it's a good idea to do compression and leak down tests, you may find #4 has low compression due to wear on valves/rings, etc (one cylinder always has at least one valve partially open so you get rust on faces, bore, etc)
If it isn't within 10% of the other cylinders it will never run right