I have a 1972 CB750K2 and a 1974 CB750K4 and they both have 17/48 stock set up. Really is the best way to go as Scottly points out. I can ride on the highway all day with this set up (yesterday was on the K4 for a 364 mile ride to the mountains) with rpms in the 5000-6000 range at 70-85 mph.
In June it was a 3000 mile round trip ride down to North Carolina on the K4 again with no issues on the highway - can pass just fine
. No buzziness/vibrations - helps if you tighten up all those loose bolts once in a while.
When I had the K4 in Europe I was on the German autobahn (no speed limit for most of it) for hours at a time ~100mph for a lot of it with high rpms - again no issues.
Change to 17t on the front you wont be sorry.
Andy