The CB550 wasn't introduced until 1974. How can you have a 72 CB550? A hybrid of parts? What carbs do you have?
The MAC 4-1 with silencer requires no jetting change from stock on a CB550K engine expecting a 4 to 4 exhaust.
#38 pilot, Needle in the 4th clip from the top, and #100 mains. Float height 22mm. For the earlier non-PD carbs.
Don't know why you are using D8 plugs, I always hated them in favor of the D7.
For the early style carbs, turning the air screws outward will make the throttle twist response wheezy and stumbly as it leans the idle mixture. Opening the slide then raises the throat pressure, reducing fuel jet flow along with an inrush of air. The idle mix has to be over rich to gain RPM reliably.
I don't believe you can properly compensate for this by raising the slide needle, and reducing main jet size.
Of course, I also don't believe the stock bike had a "flat spot" either. At least, not until ethanol was added to the gas.
Do check the plugs for soot deposits. That can cause a "flat spot" all on it's own, until temps come up to clean off the soot from an over rich mid range setting.
Does the "Hesitation" recovery burble back to life, or resume cleanly, as though suddenly "switched on"?