I sound like a broken record on forums lately, but my CB750 (1972 frame, ? early K motor & carbs, screened velocity stacks Triple A 4-1 header connected to an unknown megaphone and baffle) has always run just fine with stock 1972 K2 jetting in it. No matter what I did to it. Sometime is ran better, sometimes worse, but always pretty good. At the moment, having just got it back on the road with the opened stacks, I'm going slightly lean around 1/2 throttle, maybe 2/3. Most riding is done on the needle, not the main jet (unless you are drag racing). I think your mains are WAY too rich for a mildly modified bike, especially one with an accelerator pump (or am I not thinking of the right carbs?). Fit a richer slow jet, find a few richer needles and go back down to about a 125 main and I think you'll be in the ball park. Are you at sea level?