Geez, and I thought I was a mercenary bastard, only 3 replies and two of them are trying to part you from your bike, ha ha!
Anyway, the F2 is a great bike, but "can" be fragile, it's not a given that the one you're interested in will have any problems, particularly if it's a well loved, and well maintained, example. My previous F2 was such a bike, and was as reliable as any K bike I've ever owned.
The benefits of the F2(and F3 as they're the same bike)is that it is the best handling, best braked, and fastest of all the 750 family, as it wes specifically designed to combat bikes like Suzuki's GS750 and Kawasaki's KZ650, as both bikes were killing Honda's sales of CB750's.
Coversely The F/F1 and K7/K8 have probably the best engine as far as reliablity goes, but they're ugly, and it can be claimed that they were responsible for the untimely demise of the SOHC 750 and the rushed release of the early DOHC750's which were just as ugly, and unreliable to boot. (a good thing to do to them)
I've got a restored F2 and an unrestored "bitsa" K2, so I've decided to build a better K, utilising the beauty of the K0-K6, with the power and the handling prowess of the F2.
Basically I'll fab mounts for the rear MC on the K2 frame, then swap out the entire F2 front and rear end, the F2 engine, (but with a worked over 836CC K2 top end and Keihin CR29mm carbs)topped off of course with the K2 tank, seat, sidecovers etc. This I believe is the ultimate CB750 and will be great fun as a coversation piece at my "Old Farts" Ulysses Club meetings fooling guys who thought they new their 750's with my "factory look" CB750K9, ha ha! Cheers, Terry.