It will apply over the epoxy primer.
Draw back is its more work than basecoat/clearcoat Requiring multiple coats and lots of elbow grease to get the same depth/shine.
I picked up a gallon of red base coat for $9 the other day. I'd shop around at the paint dealers and specifically watch for the mismatched stuff if your not set on a particular color.
If you are set on a particular color the basecoats are running about $20 a pint. Which will paint the whole bike more or less.
Factor in the cost of clear. Good thing is...the clear works with all the base colors.
I talk a little about the 350 I just painted here :
http://www.sohc4.us/forums/index.php?topic=19990.0Good luck.