Yeah this will be tough with the engine in the frame. I think it can be done though, with patience and time.
1.Try soaking it with penetrating oil before trying any of these.
2.I've had good luck with easy outs but they are brittle and can break so go slow, be careful and buy 3-4 of them.
3. If any if the bolt is sticking out of the case try slotting it with a dremel, hacksaw or file and then use a flat head bit in a ratcheting drill driver, in reverse of course. Push hard and go slow.
The bolt in my spare engine broke off while I was tearing it down for rebuilding. I took the whole engine apart turned it upside down, soaked it with penetrating oil and used an easy out.