I don't see the point. The original engine is very reliable and, in my opinion, it is powerful enough.
I could understand changing the engine for another one more reliable, to keep the bike looks. But the very charisma of the CB750 lies in the engine. Taking the annoyance of transplanting the engine seems like a waste of time, why don't just switch to a modern bike instead?
Believe me, I have other old bikes -spanish made- and they are a big PITA, not just because of engine leaks, but because of multiple small fixes in the rest of the bike systems, be it brakes, electrics, you name it. Having a CB750 is having a classic bike with the convenience of a modern one.
That being said, if I had to pick one, I would pick the CB750 Nighthawk engine. It is 73 CV, DOHC, oil radiator, inline four, and oil-actuated rockers - no adjustment ever. And, it is made by Honda, so the Heritage is not spoiled....