My own experience is with a 1971 CB750 that has been in our family since new. My Dad rode the heck out of it the first few years, racking up over 15K miles with nary a problem. I took it over in 1978 and proceeded to add another 19K. At around 24k (in the early 80's), I noted a bit of oil weep around the head. I pulled the motor and had the top-end serviced. The mechanic actually chewed me out for wasting his time - there was nothing wrong with the engine that he could see, but the new gaskets did take care of the leak. I continued to use the bike as my regular ride up until 1989. A used '81 GoldWing got the majority of my attention after that. I still rode the 750 occasionally, and kept it stored out of the weather when not in use.
Fast forward to 2006. My regular ride these days is a '99 Valkyrie Interstate, but the 750 still has a special place in my heart. For the past few years, I've been gathering all the major parts I was going to need to do a full-on restoration (exhausts, seat, fenders, etc.) I just recently tore down the motor's top end (the weeping had returned) and was amazed to see how fantastic the inside of this engine looks. No hint of wear on anything! I measured the cylinder bores and checked for roundness - all well within spec. Even the clutch (original) shows no sign of wear! I had the head serviced at a local machine shop and the tech was impressed by the overall condition.
Yeah after 20+ years or 30K miles you may well expect to replace some seals, or gaskets - but it's great to know the major components stand the test of time & miles! It's a shame the engine has to come out to do this work, but it's a good opportunity to check over all the other non-engine components...