Brian,
I don't know anyone that made them work really well on the street , but if it's for track use maybe it'll be easier to dial them in. I read that Rob Lloyd suggested to start with 120 mains, needle clip second from the top and one size leaner pilots. He also suggests the underside of a 500/550 tank will need some gentle persuasion (read hammer) to help make these carbs fit.
Let us know how things turn out.