80 miles using 3.76 gallons is 21 MPG. Did you drive on and add miles after switching to reserve?
The owners manual states the tank is 4.2 US gallons including 1 gal in the reserve supply.
That's pretty sucky mileage for a cb550, imo.
For comparison my all stock 76 CB550F gets pretty near 50MPG on a road trip through the twisties. My 77 Cb550 is quite similar, though I haven't calculated it in a while.
Do you turn off the fuel tap when stopped? Sure you aren't leaking it out somewhere. If not, check your spark plugs for soot.
Cheers,