Lift the valve about 1/4" off its seat, then measure the 'wiggle' it can be moved toward the center of the combustion chamber and back toward its port. This is Honda's "spec clearance" value. When the valves can move more than 0.0032" on the intake side, Honda says it's time for new guides: while this spec if the same for exhaust, they run OK to about 0.0050" of wiggle in real life. I have found that if they move more than 0.0025" (intakes) they start to run pretty hot: depending on how you treat your steed, this can either help keep them cleaner than normal, or overheat them. If they are more than 0.0040" (intakes) then it is DEFINITELY time for new guides.
If your 750 was made after 1972, chances are the guides are pretty loose. They switched to simple cast-iron guides early in the K3 or late in the K2 (depending on which factory made the head), which was OK when we had leaded gas: when the lead went away, so did their lube system. Ethanol turns the valve stems into lapping rods because the iron cannot descale the steel shafts without lead or at least some bromide, both which are missing in fuels with ethanol. So, replace them with bronze next time, and they will probably outlive the rest of the engine.
