They are heavy to be sure. They have an alloy rim and hub with steel spokes. If you do a modern front end swap and retain the wheels (and get the matching rear) they will almost certainly weigh less.
OEM wires with aluminum rims swapped on will be quite a bit lighter than the Comstars. I have vintage Lester alloys on my 750F and I also have a set of Comstars from an F3 parts bike I picked up. The Lesters don't really feel any lighter when I lift them. The benefit of the alloys (and Comstars) over wires is the ability to run tubeless and they don't ever need to be trued.
Wheel compatibility is definitely a thing. Modern wheels typically have thicker axles, not an issue with the front if you are installing the matching fork too. The back may require a custom axle or spacers. Also keep in mind the modern wheels are usually much wider than the skinny OEM (your rear Comstar is 2.15" wide), so you can run into tire and chain clearance issues.
All said said, there have been plenty of bikes built using modern front ends and modern wheels. It just requires planning.
Unless you are planning to race, I wouldn't worry about shaving a few pounds off the wheels.