Kevnz, the tiny O-rings around the main jets are, apart from the floatbowl gaskets, the only O-rings I had to replace. Yes, they can cause trouble. Here is what to do. After removing the main jet, inspect the bore it sat in. The bores on mine after 49 years and over 140.000kms are stil immaculate, but I have read that in the US, where they have always opted for the cheapest option and so have degraded fuel with extreme high doses of MTBE, they can be damaged. The original size of the O-rings, 4,2x1,1 is good. I did not have to go bigger. Just push the main jets with their new O-rings in. Do not be tempted to twist the main jets whilst pushing them in. This to avoid their O-rings becoming damaged. I have the original O-rings by Honda and 5% ethanol gas is no problem, 10% could be problematic.
I'm sorry that in this thread some posters still mix up the oldstyle carbs with the later PD carbs. You have the old style Keihin (either 627B, 649A, 022A, 087A or 069A) and they have airscrews in the sides. For once and for all: turning them in, enrichens, turning out, leans. Small increments of 1/8 of a turn can already make a big difference. Use the settings Honda communicated as a starting point if the air intake is original even if you have aftermarket exhausts.
The PD carbs on the K3 models have a different concept. Let's not discuss them here.
A common mistake people make, is that they apply a method which in itself is sensible for many cars and even motocycles: aiming for a highest rpm at idle, by adjusting the airscrews. But... the carbs on those vehicles will have special acceleration jets. Yours and mine have none. So if you do that practice on your model, you will no doubt arrive at a very nice idle - the engine will pur like a kitten - BUT driveability is gone, meaning: acceleration will be poor. An idle mixture on your and my model needs to be on the rich side to guarantee a good driveability. That's what I mean when I say the slow jets also function as auxilary jets in acceleration. I have composed an overview of setting data for these carbs that so far has not been amended. It's about the oldstyle Keihins only.