These bikes can run very lean, and for a long time, with no ill effects on the engine. You'll know it is getting toward the limit when there is a slight 'stumble' when the throttle is rolled heavily ON while in the upper gears (3, 4) and above 4000 RPM. It won't hurt the engine, no way, no how: there were some [brand X] bikes out there in the CB750's day that could cook the pistons or burn the valves when doing this, but the 750 isn't one of them. In truth, I have run these with #95 mainjets when tinkering with this back in the 1970s, and with the needles all the way 'down' to the #1 clip site, and all that happened was: the top end wouldn't exceed 95 MPG on a flat road. Oddly enough, the float bowl level had/has more effect on the top speed than the jetting: I think that's because the last 1/8 slide opening doesn't change the speed of the engine any (the carb's already FWO by then).
I DID finally get the sparkplugs to stay white after the usual 10-mile test run out to the lake and back, though: it also felt kind of cold-blooded with the #95, not wanting to increase speed readily in 5th gear at hiway speeds. I had to wind it up to at least 6500 RPM in 4th to get it over 5000 RPM in 5th gear, lest it fall back down. That was about the only "ill effect" I had with the experiment. I did all the test runs with the needles in the top position (only wanted to pull the carbs twice overall, to start it and to end it).
At the time, I was trying to figure out how Honda was getting their advertised 50 MPG, though I was using a K2 to do it (mine), since I get closer to 35-40 MPG. The K4-5 cam is slightly later-opening at the intake valve and the #2 and #3 intake valves open 1-2 degrees later than the #1-#4 intakes on those unique cams (I have one of these in a box downstairs, came from a K5 that got a Megacycle in the rebuild). This is the "marque" of one of those so-advertised bikes, and they run silky smooth. But they won't get 100 MPH top end in normal tune. Since our 'world' was at 55 MPH then, it didn't much matter?