Seamus,
I'm running 115 mains with my Yoshi 810, Yoshi Daytona cam (high rpm hp cam), stock carbs, Kerker exhaust. I THINK my needles are in the stock position. HOWEVER I'm also at 7000 feet elevation. If you have 350 pistons they will have a very tall dome with high compression. Probably a real 810 kit. Pistons look more flat top. If you have a high perf cam that provides more mid range HP than mine you may also need to lower your needle clips thus raising the needles for more mid range fuel delivery.
Jerry