If you are an experienced welder , building a jig should not be a problem, just think it thru..
Whatever you use to hold your frame. I would work off the engine mount holes being level, with engine out, and work from there. Keep in mind, unless you have a very rigid fixture, frame may require minor tweaking after welding.
Something tells me you may not be ready, I mean you have not even mentioned what you want to build off of, ie table , or I beam, etc. There is many ways to do it IF you FULLY understand the task at hand.
If you need a lot more info than has been given, you may not be ready for this...