I have a 1972 CB750K2 with HM300 pipes and stock carbs/airbox. My jetting is mains 120, pilot 40, forget the needle clip position but believe its stock. I tried main jets from 110-112.5-115-117 to 120 before I got it right (was getting popping on decel).
Check your jets by popping off the bowl on #1 or #4, try the exhaust and see how you get on then make changes if needed.
good luck
Andy