I've spent considerable time changing elevations (with my 750) and haven't run into significant troubles, ever. On those trips when I've planned on spending lots of time above 8000 feet altitude I will turn in the idle screws slightly (about 1/8 turn) while I'm there. When I drop back down to the more-average out-West altitude (around 3500-ish feet) I'll back it back out again, but that's about all it's ever needed.
I do remember when we (6 of us on Hondas and one on a Kawi 500 triple) rode together on Mount Evans to 14,260 feet in heavy traffic, not getting past 2nd gear the whole trip to the top for cars in the way. The Kawi, once shut off at the top, wouldn't start. Three of us pushed it almost 1/4 mile back down the mountain before it started, which also nearly killed us all with the smoke and lack of oxygen! The Hondas didn't have any troubles, though. One was a 350 twin, the rest were all Fours of one kind or another, circa 1975.