In those early sandcast/K0 engines with the shorter camchain guide, the chain makes a slight 'jump' to the upper sprocket in some of the later heads if the newer guide is used: I ran into this (the opposite way) with a sandcast engine when I tried to drop in the newer guide - just because I had it on hand at the time. The guide's top seemed like it was too far forward by a little bit (like only 1-2mm of distance difference) so the chain would deflect when entering the top of the guide. When I got the 'correct' shorter guide it sat slightly further toward the rear of the engine, and the line of the chain from the front of the cam sprocket was a straight-down shot, no deflection at the top of the guide.
So, I think the later guides might be slightly offset toward the front of the engine via their locating pin boss(es), and/or the cam's bearings similarly in the head? I don't have a sandcast head to go measure, but that's my hypothesis at the moment? I have a K0 head from a near-sandcast engine (like 80 past the sandcast era) somewhere around here, might have to go see if I can find it, now that I'm a-wonderin'...