Ride at full speed or very close to it. Reduce the throttle a little.
If it feels like the bike will run better/ faster when reducing- too lean mj
If you can hear or feel a rich d-d-d-d behaviour- too rich mj.
This method works fine on the needle area too.
It is a little thrilling to know before the ride that I have to ride over 160- 180kmh to test full throttle to feel the acceleration and small throttle reductions.
Needle to mj area after 100kmh/+4000 rpm. Small accelerations followed by decelerations by the throttle to feel how it accelerates and behaves.
This is otherwise things that suddenly can happen during rides

CB750 stock carbs are well defined for stock and bigger bore with ported head and hotter cam.
No need to increase pilot jet.
Other carbs where the pilot jet has to be changed:
Bigger pilot will affect needle setting and main jet. Total fuel flow changed.
I have seen 2 sizes bigger pilot need 1 step lower needle and one size smaller main jet when needle and mj was correct before.
Last year I reduced pilot by 1 step (-2.5).
I had to lift needle 1/2 step by an M3 washer under the needle clip.
Increased mj 1 step too when acceleration at WOT from 180kmh was bad.
This on my K6 with 970cc and over 100whp.
Runs fine now so I can enjoy cruising around in legal speeds most of the time.

I had also issues with erratic idle, take offs and lower speeds not possible to tune. Like it ran too lean.
Bad fuel.
Changed gas station to other chain this year.
Shell is no more here. Their V-power changed to a bad fuel. Maybe too low octane and more ethanol.