I don't think that the vibration comes from the firing interval, but instead, from the engine configuration.
My sanglas 400CC has a huge cilinder, 83.5mm diameter, and a massive flywheel. Have you ever heard "it idles so slow you can count the explosions"? Well, I have managed to do that thanks to the big flywheel. 400 rpm ar attainable, it means 200 explosions per minute, or 3.something explosions per second. You can really distinguish them, but the idle must be raised a little if you want smooth transition from idle to slow speed.
Long story short, while the bike rests in the centerstand and you rev the engine, the bike moves!!!! The inertia involved in the big piston going up and down create such a vibration that can make the bike slide while on the pavement.
On the contrary, multi-cylinder bikes have smaller parts to achieve the same displacement, and therefore, the inertias are smaller. There are many V-twin's out there, just get any Yamaha or Honda catalog, and many of them have the same, if not bigger, displacement than Harleys v-twins, but japanese engines have delicacies such as contra-rotating weights to cancel the inertia effect.